Back from the Marvel werewolves reality, he discovers that his world is overrun by Deadites who are ruled by Evil Ash. What remains of humanity in the ruins of civilization, has been enslaved by the Deadites or mutated (e.g. multi arms, third eye, horns, tail, multi breasts, etc). As the Chosen One, Ash Williams joins forces with super-powered mutated humans. As they battle their way through Deadites in Detroit.