A wealthy scientist living in the Alabama backwoods discovers a way to allow amoeba to grow to any size. When a specimen grows to the size of a cow's liver, he instructs his son to destroy it. The son, seeing an opportunity to increase his father's fame, does not destroy the creature, and instead pays a local to bring meat to feed it. However, the amoeba grows too large and hungry, and devours the son and daughter-in-law. The father succeeds in burning the creature to death, but is driven insane with grief.
- Unnamed Narrator, a friend of the Cranmer family who determines to uncover the truth of what happened.
- John Corliss Cranmer, an accomplished and extremely wealthy scientist.
- Lee Cranmer, John's son.
- Rori Pailleron, a dim-witted local drunk who strikes a bargain with Lee.
"Ooze" was the first story in the debut issue of Weird Tales, March 1923. It has since been reprinted in several publications, including more than one Weird Tales anthology.